Inclusion complexes of cyclomaltooligosaccharides (cyclodextrins) with melatonin in solid phase
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چکیده
منابع مشابه
Melarsoprol-cyclodextrins inclusion complexes.
Melarsoprol, a water-insoluble drug, is mainly used in the treatment of trypanosomiasis and has demonstrated an in vitro activity on myeloid and lymphoid leukemia derived cell lines. It is marketed as a very poorly tolerated non-aqueous solution (Arsobal). The aim of our work was to develop melarsoprol-cyclodextrin complexes in order to improve the tolerability and the bioavailability of melars...
متن کاملSolid state characterization of α-tocopherol in inclusion complexes with cyclodextrins.
The alternative for a pure soluble, sensible for physical and chemical conditions oil form of α-tocopherol (α-T) is its complexation with cyclodextrins. A different influence of cyclodextrins on the included substance demands a stability investigation of the substance enclosed in a host-guest complex. Hence, the thermal stability of α-T in inclusion complexes (InCs) with cyclodextrins (CDs) was...
متن کاملSolid inclusion complexes of vanillin with cyclodextrins: their formation, characterization, and high-temperature stability.
This study reports the formation of solid vanillin/cyclodextrin inclusion complexes (vanillin/CD ICs) with the aim to enhance the thermal stability and sustained release of vanillin by inclusion complexation. The solid vanillin/CD ICs with three types of CDs (α-CD, β-CD, and γ-CD) were prepared using the freeze-drying method; in addition, a coprecipitation method was also used in the case of γ-...
متن کاملInclusion complexes of poorly water-soluble drugs with glucosyl-cyclodextrins.
glucosyl-ƒ¿-CD (G-ƒ¿-CD), 6-O-ƒ¿-D-glucosyl-ƒÀ-CD (G-ƒÀ-CD), and 6A,6D-di-O-ƒ¿-D-glucosyl-ƒÀ-CD (2G-ƒÀ-CD) with slightly soluble or insoluble drugs in aqueous solution and in the solid state was studied by the solubility method, ultraviolet spectroscopy, and differential scanning calorimetry. These glucosyl-CDs were capable of forming inclusion complexes with compounds which can form complexes ...
متن کاملInclusion complexes of trihexyphenidyl with natural and modified cyclodextrins
The solubility of trihexyphenidyl (Thp) was improved by its combination with β-cyclodextrin (β-CD) and modified β-CDs. The solubility of Thp was found to be increased in the presence of β-CD, hydroxypropyl-β-cyclodextrin (HP-β-CD), methyl-β-cyclodextrin (Me-β-CD) and sulfobutylether-β-cyclodextrin (SBE-β-CD). In particular, the solubility of Thp in conjunction with SBE-β-CD was increased by a f...
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ژورنال
عنوان ژورنال: Arkivoc
سال: 2005
ISSN: 1551-7012
DOI: 10.3998/ark.5550190.0006.e14